‘Of course, that is about appropriate. I search for a Bodily idea of biological techniques inside of a bottom-up way. I believe you could possibly distinguish three traces of investigate in my group at this time. The very first worries chromosome composition: how do you obtain a metre-very long DNA polymer folded and organised in this kind of microscopic cell? We've designed visualisation procedures that allow us to study how, one example is, SMC proteins loop DNA (online video on Youtube) to be able to Make up chromosomes.
You regularly get entangled in discussions about science and religion. You may have also composed several textbooks on the subject. Don’t you think that in some unspecified time in the future We'll know everything and that God’s job is going to be over?
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Our perform was swiftly followed up by Other folks, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 revealed their results on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial cell division; and initially ever study in the dynamics DNA supercoils and the invention of supercoil hopping
Our investigate ranges within the biophysics of DNA to artificial cells and outside of. You should take a look under with the spectrum of our existing assignments.
We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess ceesdekker the fundamental role of spatial confinement at the molecular and mobile level. Our jobs include the subsequent:
Example (one) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is proven in gray, the rim from the pore is highlighted in purple, along with a 3D rendering of your motion of the DNA rod is shown.
‘Sure, I fully grasp individuals ended up surprised at time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it experienced turn into a bit bored, I didn’t understand much any more. The sector went more into the application aspect, how you could integrate nanotubes into electronic circuits.
But carbon nanotubes have remained a investigate subject matter of appreciable fascination to a lot of. Without a doubt, the outlook on employing carbon nanotubes to create useful gadgets, in locations like radio-frequency electronics, digital electronics and versatile electronics, stays vivid.
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
2006, first demonstration of molecular sorting within a lab over a chip using biomotors; discovery of nanobubbles in sound-condition nanopores; and to start with estimate of electrokinetic Power conversion in the nanofluidic channel
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
Sound-state nanopores have verified for being a astonishingly adaptable probe for solitary-molecule Examination of DNA. I will describe some of our recent findings – specifically DNA knots – and our endeavours to develop the abilities of reliable-condition nanopores even more, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.